Monotonicity of Kinetic Proofreading
نویسندگان
چکیده
منابع مشابه
Speed, dissipation, and error in kinetic proofreading.
Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and microtubule growth which share some of the features described above. Our analogy re...
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T conversion of an event or signal outside the plasma membrane of the cell to one inside the membrane, called signal transduction, often involves an extended reaction cascade. Usually, the process must be remarkably sensitive and selective; however, the relative inactivity of the cell in the absence of a signal cannot be sacrificed to obtain sensitivity. Many cell responses are mediated by rece...
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Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gen...
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We apply information theoretic and energetic constraints to a key problem in cell signaling. While the cell signaling modeling process generally starts with assumptions about the system’s structure, additional assumptions about the system’s performance objectives can be used to compensate for insufficient data. In our work, we obtain parameters for a model of signal transduction across a T-cell...
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When multivalent ligands attach to IgEs bound to the receptors with high affinity for IgE on mast cells, the receptors aggregate, tyrosines on the receptors become phosphorylated, and a variety of cellular responses are stimulated. Prior studies, confirmed here, demonstrated that the efficiency with which later events are generated from earlier ones is inversely related to the dissociation rate...
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ژورنال
عنوان ژورنال: IFAC-PapersOnLine
سال: 2016
ISSN: 2405-8963
DOI: 10.1016/j.ifacol.2016.12.144